描述:Spring Bioscience,Spring Bioscience代理,BRAF V600E
Spring Bioscience代理,spring bioscience絲氨酸/蘇氨酸蛋白激酶B-RAF(BRAF)是Raf家族的一員。 BRAF突變在良性和惡性腫瘤是常見的。 BRAF改變和突變誘導(dǎo)激活段的構(gòu)象變化中BRAF V600E突變占絕大多數(shù),導(dǎo)致組成型激酶活性的BRAF的和下游目標連續(xù)的磷酸化。已在黑色素瘤,甲狀腺乳頭狀癌,多形性xanthoastrocytomas,朗格漢斯細胞組織細胞增生癥,卵巢交界性腫瘤,節(jié)細胞膠質(zhì)瘤,結(jié)直腸癌,毛細胞型星形細胞瘤檢測到BRAF V600E突變。
Spring Bio,Spring Bio代理,Spring Bioscience
PRODUCT DETAILS: | |||
TechnologyMouse Monoclonal | |||
Clone NameVE1 | |||
ApplicationIHC-P, WB | |||
Species Reactivity | |||
TestedHu | |||
Predicted by homology | |||
IsotypeMouse IgG2a | |||
ImmunogenSynthetic peptide representing the BRAF V600E mutated amino acid sequence from amino acid 596 to 606 (GLATEKSRWSG) | |||
Cellular LocalizationCytoplasm | |||
Control TissueColon Carcinoma with BRAF V600E mutation | |||
Regulatory RatingResearch Use Only (RUO) | |||
Entrez673 | |||
Storage Requirement2-8°C | |||
Target Molecular Weight95 kDa | |||
FormulationRefer to Data Sheet | |||
Catalog No. | Volume | Dilution | |
E19290 | 0.1ml | 50 | |
E19292 | 0.5ml | 50 | |
E19294 | 1.0ml | 50 |